![]() ![]() ![]() When the organizer was first described, it started one of the first truly international scientific research programs: the search for the organizer molecules. Our group investigates these early molecular events in order to understand how these processes occur. The dorsal blastopore lip forms the dorsal mesoderm and eventually becomes the chordaneural hinge that induces the tip of the tail. We are interested in how this process occurs, and if there are differences between cell-autonomous and non cell-autonomous neural inducers with respect to their downstream targets. In the frog, Xenopus, one of the signals is retinoic acid (RA). The first sign of invagination seen in the frog is the dorsal lip. It has been demonstrated that in fact inhibition of BMP signals is sufficient to induce tissue with anterior telencephalic neural character. The dorsal lip of the blastopore is the mechanical driver of gastrulation. Inhibitory signals from the dorsal blastopore lip (the Organizer) of the Xenopus embryo at gastrula stages will induce neural tissue. Abstract Coordinated polarization of cells in the. Before neural tissue is induced in the embryo, signals are required to inhibit the ectoderm from becoming epidermis so that it will become neural. DOI: 10.1101/2021.83 CC BY-NC-ND 4.0 Authors: Pamela Mancini Olga Ossipova Sergei Y. The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate. The development of the nervous system is a complex process, of which the underlying mechanisms are slowly beginning to be elucidated. the dorsal blastopore lip in frogs, the shield in fish, and the node in amniotes, with the emboly of more rostral, prechordal mesoderm preceding the internalization of chordamesoderm. The axial mesoderm moves through the axial aspect of the blastopore (Figure 2 C,D), i.e. We investigate how the ectoderm is induced and what it gives rise to, in particular how neural tissue is specified. Fibronectin might provide a permissive signal for elongation and. We are interested in understanding the molecular mechanisms of ectodermal specification in Xenopus leaves.
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